Amides can be converted to 1°, 2° or 3° amines using LiAlH4.
General Reaction
| Example 1: Amide Reductions |
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Alkyl groups attached to the nitrogen do not affect the reaction.
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Mechanism
1) Nucleophilic attach by the hydride
2) Leaving group removal
3) Nucleophilic attach by the hydride
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