Conversion of Amides into Amines with LiAlH4
April 12, 2023 2023-04-12 18:17Conversion of Amides into Amines with LiAlH4
Amides can be converted to 1°, 2° or 3° amines using LiAlH4.
General Reaction
| Example 1: Amide Reductions |
|---|
|
Alkyl groups attached to the nitrogen do not affect the reaction.
|
Mechanism
1) Nucleophilic attach by the hydride
2) Leaving group removal
3) Nucleophilic attach by the hydride
